SPERM DNA FRAGMENTATION IN INFERTILE MEN OF KUZBASS
| Autor: | Алексей Геннадьевич Тришкин, Антон Игоревич Лесников, Лилия Владиславовна Курганова, Константин Александрович Луговой, Алексей Дмитриевич Бушмакин, Галина Павловна Зуева, Алексей Андреевич Шмелев, Светлана Ивановна Елгина, Вадим Гельевич Мозес, Елена Владимировна Рудаева, Кира Борисовна Мозес |
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| Jazyk: | ruština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Мать и дитя в Кузбассе, Vol 23, Iss 1, Pp 36-40 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1991-010X 2542-0968 |
| Popis: | The standard method for diagnosing male infertility involves a spermogram, which does not always give a complete picture of male fertility. One additional method for assessing ejaculate is the sperm DNA fragmentation test (SDF), which determines the integrity of the paternal genome. Objective – to study sperm DNA fragmentation in Kuzbass men and evaluate potential relationships between the level of DNA damage, clinical parameters, and spermogram parameters. Results. The results of the study demonstrate a significant statistical relationship between DNA fragmentation of spermatozoa with progressive motility (p < 0.049), age (p < 0.040) and body mass index (BMI) (p < 0.028). Also, %SDF is significantly higher in asthenozoospermic patients (p < 0.004) than in normal patients. A correlation with %SDF was observed in terms of general (r = -0.265) and progressive (r = -0.254) mobility, viability (r = -0.205), as well as clinical parameters, age (r = 0.331) and BMI (r = 0.279). Conclusions. The study found a relationship between DNA fragmentation and motility, viability of spermatozoa, age of patients and their BMI. |
| Databáze: | Directory of Open Access Journals |
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