Marcadores de envolvimento sistêmico no lúpus eritematoso crônico discóide Markers of systemic involvement in chronic discoid lupus erythematosus

Autor:	Carolina Reato Marçon, Mariane Regina de Moraes, Soraia Maria Lanzelotti, Débora Regina Cunha Simis, Gilberto Santos Novaes
Jazyk:	English<br />Spanish; Castilian<br />Portuguese
Rok vydání:	2004
Předmět:	lúpus eritematoso crônico discóide lúpus eritematoso sistêmico autoanticorpos marcadores sistêmicos no LECD chronic discoid lupus erythematosus systemic lupus erythematosus autoantibodies systemic markers in CDLE Diseases of the musculoskeletal system RC925-935
Zdroj:	Revista Brasileira de Reumatologia, Vol 44, Iss 5, Pp 333-338 (2004)
Druh dokumentu:	article
ISSN:	0482-5004 1809-4570
DOI:	10.1590/S0482-50042004000500004
Popis:	OBJETIVO: comparar as características clínicas e o perfil dos autoanticorpos entre o lúpus eritematoso crônico discóide (LECD) e o lúpus eritematoso sistêmico (LES), com o intuito de identificar algum marcador associado ao envolvimento sistêmico no LECD. MÉTODOS: foram estudados 16 pacientes com LECD e comparados a 17 pacientes com LES, segundo os critérios do Colégio Americano de Reumatologia (ACR). Foram avaliadas as características demográficas, clínicas e pesquisados os seguintes autoanticorpos séricos, como fator antinúcleo (FAN), anti-DNA, anti-Sm, anti-Ro/SS-A, anti-La/SS-B, anti-ENA/RNP e anticardiolipina IgG e IgM. Nos pacientes com LECD foi realizada biópsia da pele e estudo histopatológico. Para comparação entre LES e LECD foi aplicado o teste do qui-quadrado. Foi considerado significativo pOBJECTIVE: to assess the clinical characteristics of CDLE, its interrelationship with SLE as well as the significance of some serum autoantibodies as markers of systemic involvement in CDLE. METHODS: sixteen patients with CDLE were compared to seventeen patients with SLE according to the ACR criteria. Clinical and demographics characteristics and serum autoantibodies like antinuclear antibodies (ANA), antibodies to dsDNA, Sm, Ro/SS-A, La/SS-B, ENA/RNP, and anticardiolipin antibodies IgG and IgM were determined. The statistical evaluation was carried out using Chi-square test. A probability level of =0.05 was considered significant. RESULTS: age and disease duration in CDLE patients were significantly longer than in patients with SLE (p
Databáze:	Directory of Open Access Journals
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