| Autor: |
Liuying Zhu, Weiwei Zhang, Ping Song, Wanzhen Li, Xiaolu Chen, Fei Ge, Lin Gui, Kai Yang, Yugui Tao, Du Guocheng |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Materials Research Express, Vol 9, Iss 4, p 045401 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2053-1591 |
| DOI: |
10.1088/2053-1591/ac65e3 |
| Popis: |
Traditional chemotherapy remains the primary cancer treatment, but it shows low enrichment and non-specificity. Hence, we have designed a multifunctional nanocarrier based on glutathione (GSH)-responsive mesoporous silica nanoparticles (MSNs). Firstly, disulfide bonds were linked on the surface of mesoporous silica. Then, doxorubicin (DOX) and chlorin e6 (Ce6) were co-loaded into the pores. Finally, carboxymethyl chitosan (CMCS) coated the nanoparticles to obtain the DOX/Ce6@MSN-SS-CMCS (DOX/Ce6@MSC) nanocarrier. The synthesized DOX/Ce6@MSC showed good monodispersity, dimensional stability, and consistent spectral characteristics. DOX/Ce6@MSC could effectively enter cancer cells and successfully deliver drugs. Under 660 nm laser irradiation, DOX/Ce6@MSC exhibited an effective photodynamic therapy effect that resists MCF-7 cells by triggering reactive oxygen species production. Thereby, it could efficiently inhibit cell proliferation and induce cell death. Anticancer analysis of tumor-bearing mice demonstrates that the DOX/Ce6@MSC combination treatment induced cell apoptosis effectively and showed an excellent antitumor effect in vivo . Therefore, DOX/Ce6@MSC nano-drug delivery system could be an effective strategy in cancer treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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