Estudios de intervención dirigidos a disminuir el riesgo de padecer diabetes mellitus tipo 2 Intervention studies aimed at lowering the risk of type 2 diabetes mellitus

Autor: José Luis Valenciaga Rodríguez, Daysi Navarro Despaigne, Orestes Faget Cepero
Jazyk: Spanish; Castilian
Rok vydání: 2003
Předmět:
Zdroj: Revista Cubana de Endocrinología, Vol 14, Iss 3, p 0 (2003)
Druh dokumentu: article
ISSN: 0864-4462
1561-2953
Popis: Los estudios de intervención en población de riesgo, dirigidos a disminuir la frecuencia de la aparición de la diabetes mellitus tipo 2 (DM 2), son considerados orientadores para el enfoque del trabajo con esos pacientes. El objetivo del presente estudio es revisar los resultados de investigaciones dirigidas a disminuir el riesgo de padecer DM 2. Los sujetos estudiados presentaban alguna de las siguientes condiciones: glucosa alterada en ayunas (GAA) o tolerancia a la glucosa alterada (TGA), antecedente personal de diabetes gestacional y síndrome metabólico. Se citan, entre otros, DPP (diabetes prevention program), DPS (diabetes prevention study), STOP-NIDDM (study to prevent non-insulin-dependent diabetes mellitus), Hiperglucemia en ayunas, DAISI (dutch acarbose intervention trial), Da Quing (estudio chino), TRIPOD (troglitazone In the prevention of diabetes), intervención, XENDOS (xenical in the prevention of diabetes in obese subjects), WOSCOPS (west of scotland coronary prevention study), EDIT (early diabetes intervención trial), NAVIGATOR (nateglinide and valsartan in impaired glucose tolerance outcomes research), DREAM (diabetes reduction assessment with ramipril and rosiglitazone medication). Estos consistían en cambios de estilo de vida (fundamentalmente ejercicios físicos sistemáticos y orientaciones nutricionales) y/o intervenciones terapéuticas. Se concluye que en personas con 25 o más años de edad de ambos sexos, con riesgo de padecer DM 2, la adopción de un estilo de vida saludable logra disminuir el riesgo de padecer el síndrome diabético. En sujetos con alto riesgo de DM 2, los fármacos que reportan mejores y más consistentes resultados son el metformin y la acarbosa. Otros como la nateglidina, rosiglitazona, ramipril y valsartan, se están investigando actualmente.Intervention studies on population at risk aimed at lowering the frequency of occurrence of type 2 diabetes mellitus(DM2) are considered as guiding lines for the work with these patients. The objective of the present study is to review the results of research works aimed at lowering the risk of suffering from type 2 diabetes mellitus. The studied subjects presented with some of the following conditions: altered glucose at fasting or altered glucose tolerance, personal history of gestational diabetes and individuals with metabolic syndrome. The following studies are quoted among others: DPP (diabetes prevention program), DPS (diabetes prevention study), STOP-NIDDM (study to prevent non-insulin dependent diabetes mellitus), Hyperglycemia at fasting, DAISI (Dutch acarbose intervention trial), Da Quing (a Chinese study), TRIPOD (troglitazone in the prevention of diabetes), XENDOS (xenical in the prevention of diabetes in obese subjects), WOSCOPS (west of Scotland coronary prevention study), EDIT( early diabetes intervention trial), NAVIGATOR (nateglinide and valsartan in impaired glucose tolerance outcomes research), DREAM (diabetes reduction assessment with ramipril and rosiglitazone medication). These research works consisted in changes of lifestyle (fundamentally systematic physical exercising and nutritional orientations) and/or therapeutic interventions. It is concluded that in persons aged 25 years or more of both sexes, having risk of suffering from type 2 diabetes mellitus, the adoption of a healthy life style reduces the risk of diabetic syndrome. In subjects with high type 2 diabetes mellitus risk, drugs that exhibit the best and more consistent results are metformin and acarbose. Other drugs as nateglidine, rosiglitazone, ramipril and valsartan are under research at present.
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