Excellent Outcome Following Sibling Peripheral Blood Hematopoietic Stem Cell Transplantation for Glanzmann Thrombasthenia: A Case Report

Autor: Jian hua Li, Shu wen Sun, Yuan Ai, Xue Yang, Yi ping Zhu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Pediatrics, Vol 9 (2022)
Druh dokumentu: article
ISSN: 2296-2360
DOI: 10.3389/fped.2021.776927
Popis: Glanzmann thrombasthenia (GT) is a rare autosomal recessive platelet disorder due to a qualitative or quantitative anomaly of the platelet membrane glycoprotein GPIIb/IIIa. Its clinical manifestations include mild to severe bleeding. GT diagnosis mainly depends on platelet function analysis, flow cytometry, and gene detection. Treatment methods include conservative symptomatic treatment and allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT is the only clinical radical method for GT. Herein, we report a 2-year-old boy with GT successfully cured by related identical peripheral blood stem cell transplantation (PBSCT). The platelet disorder was corrected to a normal level after PBSCT, with no significant complication related to the transplantation. Hematopoietic stem cell transplantation with full-matched donor in early stage could be a treatment option for GT.
Databáze: Directory of Open Access Journals