NPC 15669 blocks neutrophil CD18 increase and lung injury during cardiopulmonary bypass in pigs

Autor: J. M. Bator, A. M. Gillinov, K. J. Zehr, J. M. Redmond, I. C. Wilson, A. Herskowitz, J. R. Connor, R. M. Burch, D. E. Cameron
Jazyk: angličtina
Rok vydání: 1993
Předmět:
Zdroj: Mediators of Inflammation, Vol 2, Iss 2, Pp 135-141 (1993)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
09629351
DOI: 10.1155/S0962935193000201
Popis: During cardiopulmonary bypass (CPB), neutrophils become activated due to contact with extracorporeal surfaces and binding of complement fragments C3a and C5a, leading to extravasation and subsequent tissue damage. In this study, the effects of the leumedin NPC 15669 (N [9H - (2,7 dimethylfluorenyl - 9 - methoxy) car bonyl]-L-leucine), a leukocyte recruitment inhibitor, were evaluated in a pig model of CPB. NPC 15669 caused significant inhibition of CPB associated increase in CD18 upregulation, lung tissue myeloperoxidase content, and percentage wet weight compared to controls. Lung histology revealed clear airways and minimal neutrophil infiltration in treated animals vs. significant oedema and cellular infiltration in controls. It is concluded that CPB causes a dramatic increase in neutrophil CD18, and that leumedins are effective in inhibiting neutrophil activation and subsequent tissue injury when administered during CPB.
Databáze: Directory of Open Access Journals
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