Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains

Autor: Luís Borges-Araújo, Marco M. Domingues, Alexander Fedorov, Nuno C. Santos, Manuel N. Melo, Fábio Fernandes
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Chemistry, Vol 4, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 2399-3669
DOI: 10.1038/s42004-021-00603-1
Popis: Phosphatidylinositol-4,5-bisphosphates are involved in membrane regulation and signalling in eukaryotes, with the distribution of acyl chains changing in response to stimuli. Here, molecular dynamics simulations and fluorescence spectroscopy experiments show that increasing acyl chain saturation increases the ordering of lipid nanodomains in artificial membranes.
Databáze: Directory of Open Access Journals
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