KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE

Autor:	Oscar A. FLOREZ A., Gloria E. TOBÓN Z., Erika M. LOPERA G.
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	pseudopolymorphs activation energy recrystallization. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Zdroj:	Vitae, Vol 16, Iss 3 (2009)
Druh dokumentu:	article
ISSN:	0121-4004 2145-2660 96883170
Popis:	The activation energy variation can be used as a quick measure to differentiate polymorphs of active pharmaceutical ingredients. In this paper diverse phenytoin crystal habits have been obtained through processes of recrystallization in different solvents. Some of these solids differ in melting point by DSC, but are similar in XRD and FT-IR. From the results of melting point, 4 solids are selected by presenting the most dissimilar values. Their activation energy (Ea) is determined by DSC technique, using 3 theoretical isoconversional nonisothermal models and it is found even that 23 Kcal/ mol of difference separate the most extreme values.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c7cae86dd57e4933a968831709806e23 Zobrazit plný text záznamu View record in DOAJ