Phytochemical Screening and Antidiabetic Activity of Aqueous Extract of Evolvulus Alsinoides Leaves: An In Vitro and In Silico Study
| Autor: | Mukundh S Tarun, Veeraraghavan Vishnu Priya, Ponnusamy Bhuvaneswari |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1246-1248 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0976-4879 0975-7406 |
| DOI: | 10.4103/jpbs.jpbs_585_23 |
| Popis: | BackgroundNowadays, diabetes mellitus has become common worldwide due to changes in lifestyle, sedentary life, alterations in food habits, and other genetic and environmental factors. It is necessary to create awareness about the growing pandemic. AimTo evaluate the antidiabetic potential of Evolvulus alsinoides. MethodsIn vitro α-amylase inhibition and α-glucosidase inhibition activity. Molecular docking analysis. ResultsThe plant is rich in naturally occurring phytocompound. The results of the study showed that E. alsinoides has the potential to inhibit the activity of alpha-amylase and alpha-glucosidase. Moreover, this result was validated using in silico molecular docking studies that showed a good binding affinity of one of the major phytocompound, caffeic acid, with molecules in the insulin signaling cascade. ConclusionE. alsinoides has a potent antidiabetic activity and can be further employed in animal and human studies. |
| Databáze: | Directory of Open Access Journals |
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