Rational choice of hepatoprotectors for drug-induced liver injury
| Autor: | H.V. Osyodlo, M.P. Boichak, O.O. Fedorova |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Gastroenterologìa, Vol 56, Iss 3, Pp 179-189 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2308-2097 2518-7880 |
| DOI: | 10.22141/2308-2097.56.3.2022.507 |
| Popis: | The article deals with a review of the current literature on the clinical use of hepatoprotectors in drug-induced liver injury. The literature was searched in Scopus, Web of Science, PubMed and other databases. Risk factors, pathogenetic mechanisms of liver damage, international diagnostic criteria and treatment for drug-induced liver injuries are considered. Clinical and pharmacological approaches to the choice of hepatoprotectors for the management of drug-induced liver injury are substantiated. The positive effects of ademetionine, a hepatoprotector, are highlighted — choleretic, cholekinetic, regenerating, antioxidant and antitoxic. In accordance with the principles of evidence-based medicine, it has been found that the indisputable advantage of ademetionine in the comprehensive treatment of drug-induced liver injury is its high clinical effectiveness as a mean of pathogenetic treatment of cholestasis, hepatocellular lesions and their combinations. |
| Databáze: | Directory of Open Access Journals |
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