A RETRO-BIOMIMETIC ONE-STEP SYNTHESIS OF NATURAL ATISANIC AND BEYERANIC DITERPENOIDS

Autor: Olga Chetraru, Marina Grinco, Veaceslav Kulciţki, Pavel F. Vlad, Nicon Ungur
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, Vol 5, Iss 1, Pp 121-123 (2010)
Druh dokumentu: article
ISSN: 1857-1727
2345-1688
Popis: An efficient retro-biomimetic procedure for the synthesis of two natural products having atisanic and beyeranic structure is reported. The readily available ent-kaurenoic acid is used as the substrate, which provides under superacidic treatment a mixture of natural ent-beyer-15-en-19-oic and ent-atis-16-en-19-oic acids. These compounds have been reported as components of medicinal plants and possess relevant biological activity. Their structure was confirmed on the basis of chemical transformations and spectral data.
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