| Autor: |
Mohammad Nazmul Islam, Homyra Tasnim, Laiba Arshad, Md. Areeful Haque, Syed Mohammed Tareq, A. T. M. Mostafa Kamal, Md. Masudur Rahman, A S. M. Ali Reza, Kazi Ashfak Ahmed Chowdhury, Abu Montakim Tareq |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Clinical Phytoscience, Vol 6, Iss 1, Pp 1-9 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2199-1197 |
| DOI: |
10.1186/s40816-020-00212-w |
| Popis: |
Abstract Background Albizia richardiana belongs Fabaceae family which different parts like fruits, flowers, barks, and roots are used medicinally. The study reports the in vitro anti-inflammatory, thrombolytic, cytotoxicity and antimicrobial activity of methanolic extract of A. richardiana stem and its different fractions. Method The methanolic extract of A. richardiana stem (MEAR) extracted with n-hexane (HXFAR), carbon tetrachloride (CTFAR), chloroform (CFAR), and aqueous (AQFAR) and subjected for DPPH scavenging activity and total phenol content (TPC). The cytotoxic activity evaluated by brine shrimp lethality bioassay, while the disk diffusion method used for the antimicrobial study. The anti-inflammatory and thrombolytic activities of the extracts evaluated by the hypotonic solution induced hemolysis, heat-induced hemolysis and human blood clot lysis, respectively. Results All the extracts exhibited excellent antioxidant activity in the DPPH scavenging assay and maximum total phenol content observed by HXFAR. Secondly, the extract showed a moderate LC50 value in brine shrimp lethality bioassay, where the CTFAR extract exhibited potential antimicrobial activities against sixteen different microorganisms. In anti-inflammatory, all the extract exhibited a significant (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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