Engineering threshold-based selection systems

Autor: Katherine H Pedone, Vanessa González-Pérez, Luciana E Leopold, Neal R Rasmussen, Channing J Der, Adrienne D Cox, Shawn Ahmed, David J Reiner
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: G3: Genes, Genomes, Genetics, Vol 11, Iss 9 (2021)
Druh dokumentu: article
ISSN: 2160-1836
DOI: 10.1093/g3journal/jkab234
Popis: AbstractUsing model organisms to identify novel therapeutic targets is frequently constrained by pre-existing genetic toolkits. To expedite positive selection for identification of novel downstream effectors, we engineered conditional expression of activated CED-10/Rac to disrupt Caenorhabditis elegans
Databáze: Directory of Open Access Journals