The Role of Nitric Oxide and Ferritin in the Pathogenesis of Alcoholic Liver Disease: a Controlled Clinical Study
| Autor: | Azra Husić-Selimović, Jasminko Huskić, Zora Vukobrat-Bijedić, Rusmir Mesihović, Mehmed Gribajčević |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Biomolecules & Biomedicine, Vol 9, Iss 3 (2009) |
| Druh dokumentu: | article |
| ISSN: | 2831-0896 2831-090X |
| DOI: | 10.17305/bjbms.2009.2807 |
| Popis: | The role of ferritin in fibrogenesis of liver parenchyma in patients with alcoholic liver disease has been investigated in previous studies. Ferritin was shown to be an indirect marker of ferum deposition in liver parenchyma in alcohol liver disease. The aim of the present study was to examine the role of nitric oxide (NO) in the pathogenesis of alcoholic liver disease as well as the influence of NO on iron (ferritin) me-tabolism in patients with alcoholic liver disease. Serum concentrations of NO and iron markers (iron, total iron binding capacity, ferritin) were measured in 30 male patients (aged 20-60 years) with alcoholic liver disease, as well as from a control group (30 male patients (aged 20-60 years) without liver disease). NO concentration was detected by measuring production of nitrates and nitrites using classical colorimetric Griess reactions. There was a statistically significant increase in serum NO concentration in patients with alcoholic liver disease compared to the control group (mean ± SEM; 41,2 ± 25,3 vs. 28,9 ± 12,3 mmol/dm3, respectively; p |
| Databáze: | Directory of Open Access Journals |
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