| Autor: |
S.M. Adiga, K. Meena Kumari, K.L. Bairy, M. Amberkar, B.M.Vadiraja, M.S.Vidyasagar |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Al Ameen Journal of Medical Sciences, Vol 05, Iss 02, Pp 116-123 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
0974-1143 |
| Popis: |
Objective: to know the evolution of adjuvant chemotherapy treatment given and to evaluate the efficacy of two commonly used regimens. Background: Colorectal cancer in Indian population is on upward swing due to the change in dietary habits and many other factors. The treatment of colorectal cancer has changed drastically over a period of time. Method: Patients diagnosed of this cancer and treated with adjuvant chemotherapy from 1997 to 2006 in our hospital were included for the study. Patients treated from 1997-2001 were followed up for a period of five years. The efficacy of two regimens were analyzed by five year overall survival rates in the respective group. Results: 5–fluorouracil monotherapy and 5-fluorouracil with levamisole were the commonly used regimens during 1997 - 2001 whereas in the later half, 5-fluorouracil+ leucovorin was the commonest regimen. Five year overall survival was 46% & 20% in stage B & C in 5- fluorouracil + levamisole group whereas it was 36% and 10 % respectively in 5- fluorouracil monotherapy group. Conclusion: We conclude from our findings that 5- fluorouracil+ levamisole regimen had better five year overall survival than 5-fluorouracil. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
