Whortleberry protects kidney against the cisplatin-induced nephrotoxicity: an experimental study

Autor: Huseyin Eren, Hasan Riza Aydin, Levent Tumkaya, Ilke Onur Kazaz, Yildiray Kalkan, Seher Nazli Kazaz, Tolga Mercantepe, Mustafa Ozan Horsanali, Adnan Yilmaz
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Renal Failure, Vol 40, Iss 1, Pp 466-474 (2018)
Druh dokumentu: article
ISSN: 0886-022X
1525-6049
0886022X
DOI: 10.1080/0886022X.2018.1500292
Popis: Purpose: This study investigated the antioxidant effects of whortleberry against cisplatin-induced nephrotoxicity in rats. Material and methods: This study included 48 female Sprague–Dawley rats weighing 263.68 ± 8.29 g. The rats were divided into the following six groups, with eight rats in each group: control, ethanol control, whortleberry control, cisplatin control, 16 mg/kg cisplatin +100 mg/kg whortleberry, and 16 mg/kg cisplatin +200 mg/kg whortleberry groups. Biochemical analysis was performed by measuring total oxidant status and total antioxidant status, histopathological analysis was performed by calculating proximal and distal tubule areas (μm2), and immunohistochemical analysis was performed by determining anti-Caspase-3 immunostaining. Differences among the groups were examined using one-way analysis of variance, and p
Databáze: Directory of Open Access Journals
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