Membrane curvature governs the distribution of Piezo1 in live cells

Autor: Shilong Yang, Xinwen Miao, Steven Arnold, Boxuan Li, Alan T. Ly, Huan Wang, Matthew Wang, Xiangfu Guo, Medha M. Pathak, Wenting Zhao, Charles D. Cox, Zheng Shi
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-35034-6
Popis: This study demonstrates that the curvature of the cell membrane directly regulates the spatial distribution of Piezo1, a widely expressed mechanosensitive ion channel. Piezo1 may flatten upon activation and can mechanically inhibit membrane dynamics
Databáze: Directory of Open Access Journals