Regulatory T cells confer a circadian signature on inflammatory arthritis

Autor: L. E. Hand, K. J. Gray, S. H. Dickson, D. A. Simpkins, D. W. Ray, J. E. Konkel, M. R. Hepworth, J. E. Gibbs
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-15525-0
Popis: Circadian rhythms can alter inflammatory state and activity of inflammatory diseases such as rheumatoid arthritis. Here the authors show that extrinsic signals confer a circadian rhythm to regulatory T cell activity, which in turn drives rhythmic inflammation in collagen-induced arthritis.
Databáze: Directory of Open Access Journals