Mbnl1 and Mbnl2 regulate brain structural integrity in mice

Autor: Naomi S. Sta Maria, Chenyu Zhou, Se Jung Lee, Parvin Valiulahi, Xiandu Li, Jongkyu Choi, Xiaodan Liu, Russell Jacobs, Lucio Comai, Sita Reddy
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02845-0
Popis: Sta Maria et al. use 2D MRI to study brains from mice deficient in Mbnl1 and/or Mbnl2 as these Muscleblind-like proteins are thought to play a role in Myotonic Dystrophy Type I (DM1). They show brain region-specific reductions in white and gray matter that could help to explain the variability in the brain structural alterations reported in DM1.
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