The role of long-lived plasma cells in viral clearance

Autor:	Mingran Zhang, Meili Li, Junling Ma
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Viral clearance adaptive immune system basic reproduction number within-host mathematical model secondary infection 92C30 Environmental sciences GE1-350 Biology (General) QH301-705.5
Zdroj:	Journal of Biological Dynamics, Vol 18, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	17513758 1751-3766 1751-3758
DOI:	10.1080/17513758.2024.2325523
Popis:	ABSTRACTThe adaptive immune system has two types of plasma cells (PC), long-lived plasma cells (LLPC) and short-lived plasma cells (SLPC), that differ in their lifespan. In this paper, we propose that LLPC is crucial to the clearance of viral particles in addition to reducing the viral basic reproduction number in secondary infections. We use a sequence of within-host mathematical models to show that, CD8 T cells, SLPC and memory B cells cannot achieve full viral clearance, and the viral load will reach a low positive equilibrium level because of a continuous replenishment of target cells. However, the presence of LLPC is crucial for viral clearance.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7c46143c7e0740369c5afc646c5cd0c7 Zobrazit plný text záznamu View record in DOAJ