Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations

Autor:	Jan-Niklas Eckardt, Friedrich Stölzel, Desiree Kunadt, Christoph Röllig, Sebastian Stasik, Lisa Wagenführ, Korinna Jöhrens, Friederike Kuithan, Alwin Krämer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Ralph Naumann, Björn Steffen, Volker Kunzmann, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schäfer-Eckart, Christoph Schliemann, Stefan W. Krause, Regina Herbst, Mathias Hänel, Maher Hanoun, Ulrich Kaiser, Martin Kaufmann, Zdenek Rácil, Jiri Mayer, Frank Kroschinsky, Wolfgang E. Berdel, Gerhard Ehninger, Hubert Serve, Carsten Müller-Tidow, Uwe Platzbecker, Claudia D. Baldus, Johannes Schetelig, Martin Bornhäuser, Christian Thiede, Jan Moritz Middeke
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Acute myeloid leukemia Extramedullary Leukemia cutis Chloroma Myeloid sarcoma Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-13 (2022)
Druh dokumentu:	article
ISSN:	1756-8722
DOI:	10.1186/s13045-022-01267-7
Popis:	Abstract Background Extramedullary manifestations (EM) are rare in acute myeloid leukemia (AML) and their impact on clinical outcomes is controversially discussed. Methods We retrospectively analyzed a large multi-center cohort of 1583 newly diagnosed AML patients, of whom 225 (14.21%) had EM. Results AML patients with EM presented with significantly higher counts of white blood cells (p
Databáze:	Directory of Open Access Journals
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