NGAL (Neutrophil Gelatinase-Associated Lipocalin) as an early biomarker of nephropathy in patients with type 2 diabetes
| Autor: | Magdy Helmy Zikry Megallaa, Mohamed Said Abdel Salam, Neveen Lewis Mikhael Saad, Mohamed Nagy Abdel Hay Ahmed Altair, Noha Gaber Amin |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Alexandria Journal of Medicine, Vol 59, Iss 1, Pp 52-58 (2023) |
| Druh dokumentu: | article |
| ISSN: | 20905068 2090-5076 2090-5068 |
| DOI: | 10.1080/20905068.2023.2230051 |
| Popis: | ABSTRACTBackground and aim Diabetic nephropathy (DN) is a major microvascular diabetic complication representing the key leading reason for end-stage renal disease (ESRD). The current work aimed to evaluate the value of urinary and serum NGAL (neutrophil gelatinase-associating lipocalin), as an early biomarker of DN in subjects with type-2 diabetes mellitus (T2DM).Methods The study included 300 adult subjects with T2DM subdivided into 3 groups: Group A: 100 subjects with normoalbuminuria. Group B: 100 subjects with moderately increased albuminuria. Group C: 100 subjects with severely increased albuminuria.Results Serum NGAL and urinary NGAL were significantly elevated in T2DMsubjects with albuminuria than in normoalbuminuric T2DMsubjects (p |
| Databáze: | Directory of Open Access Journals |
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