Clinical Interpretation of Elevated CA 19-9 Levels in Obstructive Jaundice Following Benign and Malignant Pancreatobiliary Disease

Autor: Min Seong Kim, Tae Joo Jeon, Ji Young Park, Jeongmin Choi, Won Chang Shin, Seong Eun Park, Ji-Young Seo, Young Moon Kim
Jazyk: English<br />Korean
Rok vydání: 2017
Předmět:
Zdroj: The Korean Journal of Gastroenterology, Vol 70, Iss 2, Pp 96-102 (2017)
Druh dokumentu: article
ISSN: 1598-9992
DOI: 10.4166/kjg.2017.70.2.96
Popis: Background/Aims: Elevated carbohydrate antigen (CA) 19-9 level may be unable to differentiate between benign and malignant pancreatobiliary disease with obstructive jaundice. The study aims to determine the clinical interpretation and the diagnostic value of CA 19-9 level in pancreatobiliary diseases with coexistent obstructive jaundice. Methods: We retrospectively reviewed the data of 981 patients who underwent biliary drainage due to obstructive jaundice following pancreatobiliary disease at Sanggye Paik Hospital for 5 years. 114 patients with serial follow-up data for CA 19-9 level were included in this study (80 patients with malignancy and 34 patients with benign diseases). We compared the levels of CA 19-9 levels and the biochemical value before and after biliary drainage. Results: The rate of CA 19-9 elevation (>37 U/mL) was significantly different between the benign group and the malignant group (59% vs. 90%, p=0.001). Despite the decrease in serum bilirubin after biliary drainage, CA 19-9 levels remained elevated in 12% of patients in the benign group and in 63% of patients in the malignant group (p
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