Autor: |
Junchen Liu, Ransome van der Hoeven, Walaa E. Kattan, Jeffrey T. Chang, Dina Montufar-Solis, Wei Chen, Maurice Wong, Yong Zhou, Carlito B. Lebrilla, John F. Hancock |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
|
Zdroj: |
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023) |
Druh dokumentu: |
article |
ISSN: |
2041-1723 |
DOI: |
10.1038/s41467-023-36128-5 |
Popis: |
KRAS is a small GTPase that regulates cell proliferation. Here, the authors show that a subset of cell surface glycosphingolipids regulate KRAS plasma membrane localization by modulating inner leaflet lipid composition, uncovering a requirement for KRAS oncogenesis that may have therapeutic potential. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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