| Autor: |
Álvaro Alejandre-de-Oña, Jaime Alonso-Muñoz, Pablo Demelo-Rodríguez, Jorge del-Toro-Cervera, Francisco Galeano-Valle |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Thrombosis Update, Vol 3, Iss , Pp 100047- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5727 |
| DOI: |
10.1016/j.tru.2021.100047 |
| Popis: |
Sickle cell trait (SCT) is the carrier state for sickle cell disease (SCD) and is usually perceived as a mild condition; however, previous studies have shown that hypoxemia may trigger sickle-cell related complications in these patients, including splenic infarction. Hypoxemia is a common finding in patients with COVID-19 pneumonia.We present the case of a 19-year-old male with a history of epilepsy who presented to the emergency room due to abdominal pain in the left flank that appeared after presenting generalized tonic-clonic seizures and fever. SARS-CoV-2 RT-PCR testing in nasopharyngeal swab was positive and an abdominal computerized tomography (CT) revealed a massive splenic infarction. Hemoglobinopathy study using high-efficiency liquid chromatography demonstrated the presence of 39.7% HbS, thus confirming the diagnosis of SCT.Hypoxemia, endothelial dysfunction and hypercoagulability caused by SARS-CoV-2 infection could lead to complement activation and microangiopathy, triggering the vaso-occlusive crisis that led to splenic infarction. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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