Radical SAM-dependent ether crosslink in daropeptide biosynthesis

Autor: Sijia Guo, Shu Wang, Suze Ma, Zixin Deng, Wei Ding, Qi Zhang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30084-2
Popis: Darobactin is a ribosomally synthesized and post-translationally modified peptide featuring a unique scaffold and potent activity against Gram-negative bacteria. Here, the authors identify darobactin synthase DarE as responsible for the bicyclic scaffold formation and propose the name daropeptide for this growing class of enzymes.
Databáze: Directory of Open Access Journals