Case Report: Unmasked Inherited Dysfibrinogenemia After Everolimus Therapy

Autor: Alona A. Merkulova, Steven C. Mitchell, Sergei Merkulov, Alisa S. Wolberg, Marguerite Neerman-Arbez, Alvin H. Schmaier
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Frontiers in Medicine, Vol 7 (2020)
Druh dokumentu: article
ISSN: 2296-858X
DOI: 10.3389/fmed.2020.591546
Popis: A previously hemostatically asymptomatic patient with common variable hypogammaglobulinemia was given everolimus to prevent growth of her liver. Within several months, the patient developed a severe bleeding disorder. The bleeding was due to fibrin polymerization defect that upon sequencing was shown to be dysfibrinogenemia Krakow III. Elimination of the mTor inhibitor ameliorated the clinical bleeding state.
Databáze: Directory of Open Access Journals