LOW LEVEL OF ANTITHROMBIN III AS A WARNING SIGN FOR DEVELOPING THROMBOTIC COMPLICATIONS IN SURGICAL PATIENTS
| Autor: | K. N. Zolotukhin, Ph. Krüger, A. V. Samorodov |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Креативная хирургия и онкология, Vol 8, Iss 1, Pp 52-56 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2307-0501 2076-3093 |
| DOI: | 10.24060/2076-3093-2018-8-1-52-56 |
| Popis: | Introduction. Pulmonary embolism (PE), being the most severe embolic complication, is characterised by low predictability, high mortality and incapacitation rates as well as a correspondingly high economic cost of therapy and aftercare. In this connection, the main purpose of our work is to find a warning for PE development in non-cardiosurgical patients that have undergone intensive therapy under conditions of general surgical ICU, among the indicators of the haemostasis system.Materials and methods. Based at the anaesthesiology and emergency surgical department № 1 of the Kuvatov Republic Clinical Hospital (Russia), the researchers carried out an analysis of the haemostasis system in 430 patients hospitalised between 2010 and 2014. The functional activity of platelets was studied using a Biola 230LA laser platelet aggregation analyser (Russia). The determination of circulating aggregates was conducted using the Wu — Hoak method. Thromboelastography was carried out using a TEG 5000 Thromboelastograph (USA). A Stago STA Compact automated selective haemostasis analyser (France) was used to register indicators that characterise the state of endothelium, the haemostatic coagulation element and thrombosis and fibrinolysis markers.Results. Univariate analysis demonstrated a connection between nosocomial episodes of thrombosis and the following factors: emergency surgery (OR 9.1, p |
| Databáze: | Directory of Open Access Journals |
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