Optimization of Resolving Power, Fragmentation, and Mass Calibration in an Orbitrap Spectrometer for Analysis of 24 Pesticide Metabolites in Urine

Autor: Pablo Dualde, Clara Coscollà, Agustin Pastor, Vicent Yusà
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: International Journal of Analytical Chemistry, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 1687-8760
1687-8779
DOI: 10.1155/2019/1917369
Popis: Mass spectrometer parameters such as Resolving Power, type of fragmentation, and mass calibration mode were optimized in the analysis of 24 pesticide metabolites in human urine using Ultra-High Pressure Liquid Chromatography coupled to Orbitrap High-Resolution Mass Spectrometer (UHPLC-HRMS). The best results were achieved with a Resolving Power of 25,000 FWHM and by applying Collision Induced Dissociation fragmentation mode (40 eV).
Databáze: Directory of Open Access Journals
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