Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

Autor: Charalampos Kapsalis, Bolin Wang, Hassane El Mkami, Samantha J. Pitt, Jason R. Schnell, Terry K. Smith, Jonathan D. Lippiat, Bela E. Bode, Christos Pliotas
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-12591-x
Popis: How mechanosensitive ion channels, such as MscL, are activated by lipids and physical properties of the membrane remains unclear. Here authors use PELDOR/DEER spectroscopy and identify a single site which generated an allosteric structural response in the absence of membrane tension.
Databáze: Directory of Open Access Journals