Synthesis of PAMAM dendrimers with porphyrin core and functionalized periphery as templates of metal composite materials and their toxicity evaluation

Autor: Raquel E. Hernández Ramírez, Irina V. Lijanova, Natalya V. Likhanova, Octavio Olivares Xometl, Alfredo Hernández Herrera, J. Federico Chávez Alcalá, Octavio Trejo Chavero
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 27-36 (2020)
Druh dokumentu: article
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2017.01.013
Popis: Experiments were performed for the synthesis of meso-substituted tetraphenyl porphyrins in order to obtain growth active points for PAMAM branches and a functionalized periphery with thiazole groups for increasing the metal complexation activity. Characterization by 1H and 13C NMR, mass spectrometry and infrared spectrometry confirmed the produced dendrimeric nanostructures; the chemical reduction of metallic Ag and Cu inside the dendrimer was proved by XPS. Finally, the toxicity of the metal-dendrimer complex was analyzed by means of the bacterial respiration test. Keywords: Porphyrin, PAMAM-dendrimers, Metal complex, Metal species
Databáze: Directory of Open Access Journals