Effects of a stepwise alveolar recruitment maneuver on lung volume distribution in dogs assessed by computed tomography

Autor: Ana Flávia Sanchez, Aline Magalhães Ambrósio, Ana Carolina B. C. Fonseca Pinto, Marco Aurélio Amador Pereira, Felipe Silveira Rego Monteiro Andrade, Renata Ramos Rodrigues, Alessandro Rodrigues de Carvalho Martins, Carina Outi Baroni, Bruno Ferrante, Denise Tabacchi Fantoni
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Veterinary Science, Vol 10 (2024)
Druh dokumentu: article
ISSN: 2297-1769
DOI: 10.3389/fvets.2023.1232635
Popis: BackgroundPulmonary atelectasis is a commonly occurs during anesthesia. In these cases, mechanical ventilation (MV) associated with alveolar recruitment maneuvers (ARMs) and positive end-expiratory pressure (PEEP) is indicated to reverse the condition, ensure adequate gas exchange and improve oxygenation. ARMs can trigger volutrauma, barotrauma, and atelectrauma. Therefore, computed tomography (CT) is the gold-standard method for monitoring lung aeration after ARM.ObjectiveTo evaluate lung volume distribution after stepwise ARMs using computed tomography (CT).MethodsTwelve dogs weighing 24.0 ± 6.0 kg, aged 3 ± 1 years, of both sexes and different breeds, underwent orchiectomy or ovariohysterectomy. The animals were anesthetized and ventilated in volume-controlled mode. ARMs were then initiated by positive end-expiratory pressure (PEEP) titration (5, 10, 15, and 20 cmH2O). CT scans, cardiovascular parameters, and ventilatory mechanics were evaluated at all time points. Data were assessed for normality using the Shapiro–Wilk test and a two-way analysis of variance, followed by a post-hoc Bonferroni test to identify differences between time points. Statistical significance was attributed to a value of p of
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