Oxycodone vs. tramadol in postoperative parent-controlled intravenous analgesia in children: a prospective, randomized, double-blinded, multiple-center clinical trial

Autor: Siyuan Li, Hongfei Xiong, Yingping Jia, Zhengchen Li, Yexi Chen, Liang Zhong, Feng Liu, Shuangquan Qu, Zhen Du, Yuxia Wang, Suxia Huang, Yonghui Zhao, Jing Liu, Lihua Jiang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Anesthesiology, Vol 23, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 1471-2253
DOI: 10.1186/s12871-023-02054-8
Popis: Abstract Background Management of acute postoperative pain is one of the major challenges in pediatric patients. Oral oxycodone has shown good pain relief in postoperative pain relief in children, but no studies have investigated intravenous oxycodone in this context. Objective whether oxycodone PCIA can provide adequate and safe postoperative pain relief, in comparison to tramadol as reference opioid drug. Design a randomized, double-blind, parallel, multi-center clinical trial. Setting five university medical centers and three teaching hospitals in China. Participants patients aged 3-month-old to 6-year-old undergoing elective surgery under general anesthesia. Intervention patients were randomly allocated to either tramadol (n = 109) or oxycodone (n = 89) as main postoperative opioid analgesic. Tramadol or oxycodone were administered with a loading dose at the end of surgery (1 or 0.1 mg.kg–1, respectively), then with a parent-controlled intravenous device with fixed bolus doses only (0.5 or 0.05 mg.kg–1, respectively), and a 10-min lockout time. Outcomes the primary outcome was adequate postoperative pain relief, defined as a face, legs, activity, cry, and consolability (FLACC) score
Databáze: Directory of Open Access Journals
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