An RB insensitive to CDK regulation
| Autor: | Manel Joaquin, Eulàlia de Nadal, Francesc Posas |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Molecular & Cellular Oncology, Vol 4, Iss 1 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2372-3556 23723556 |
| DOI: | 10.1080/23723556.2016.1268242 |
| Popis: | The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays tumor cell growth. This novel mechanism of RB regulation opens up a window for developing new cancer drug treatments for tumors harboring high CDK-Cyclin activity and a wild-type RB gene. |
| Databáze: | Directory of Open Access Journals |
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