| Autor: |
Lesley A. Stewart, Mark Simmonds, Lelia Duley, Kristina Charlotte Dietz, Melissa Harden, Alex Hodkinson, Alexis Llewellyn, Sahar Sharif, Ruth Walker, Kath Wright, the EPPPIC group |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Systematic Reviews, Vol 6, Iss 1, Pp 1-17 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2046-4053 |
| DOI: |
10.1186/s13643-017-0600-x |
| Popis: |
Abstract Background Preterm birth is the most common cause of death and harm to newborn babies. Babies that are born early may have difficulties at birth and experience health problems during early childhood. Despite extensive study, there is still uncertainty about the effectiveness of progestogen (medications that are similar to the natural hormone progesterone) in preventing or delaying preterm birth, and in improving birth outcomes. The Evaluating Progestogen for Prevention of Preterm birth International Collaborative (EPPPIC) project aims to reduce uncertainty about the specific conditions in which progestogen may (or may not) be effective in preventing or delaying preterm birth and improving birth outcomes. Methods The design of the study involves international collaborative individual participant data meta-analysis comprising systematic review, re-analysis, and synthesis of trial datasets. Inclusion criteria are as follows: randomized controlled trials comparing progestogen versus placebo or non-intervention, or comparing different types of progestogen, in asymptomatic women at risk of preterm birth. Main outcomes are as follows; fetal/infant death, preterm birth or fetal death ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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