Persistence of ICD indication at the time of replacement in patients with initial implant for primary prevention indication: Effect on subsequent ICD therapies

Autor: Gabriele Dell’Era, Anna Degiovanni, Eraldo Occhetta, Andrea Magnani, Miriam Bortnik, Gabriella Francalacci, Laura Plebani, Eleonora Prenna, Sergio Valsecchi, Paolo Marino
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Indian Pacing and Electrophysiology Journal, Vol 17, Iss 2, Pp 29-33 (2017)
Druh dokumentu: article
ISSN: 0972-6292
DOI: 10.1016/j.ipej.2016.11.008
Popis: Background: Indication to implantable cardioverter defibrillator (ICD) for primary prevention of sudden death relies on left ventricular ejection fraction (LVEF). We measured the proportion of patients in whom indication to ICD persisted at the time of generator replacement (GR) and searched for predictors of appropriate therapies after GR. Methods: We identified all consecutive patients who had received an ICD at our hospital, for LVEF ≤35% and no previous arrhythmias or unexplained syncope. Then, we included the 166 patients who outlived their first device and underwent GR. Results: At the time of GR (mean follow-up 59 ± 20 months), ICD indication (i.e. LVEF ≤35% or previously treated ventricular arrhythmias) persisted in 114 (69%) patients. After GR, appropriate ICD therapies were delivered in 30 (26%) patients with persistent ICD indication and in 12 (23%) of the remaining patients (p = 0.656). Nonetheless, the annual rate of therapies was higher in the first group (1.08 versus 0.53 events/year; p
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