Microbial imbalance in Chinese children with diarrhea or constipation

Autor: Jing Ren, Yi Ren, Yu Mu, Lanying Zhang, Binghan Chen, Sisi Li, Qinyi Fang, Zhiming Zhang, Kejian Zhang, Sabrina Li, Wei Liu, Yutao Cui, Xu Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-024-60683-6
Popis: Abstract Diarrhea and constipation are common health concerns in children. Numerous studies have identified strong association between gut microbiota and digestive-related diseases. But little is known about the gut microbiota that simultaneously affects both diarrhea and constipation or their potential regulatory mechanisms. Stool samples from 618 children (66 diarrhea, 138 constipation, 414 healthy controls) aged 0–3 years were collected to investigate gut microbiota changes using 16S rRNA sequencing. Compared with healthy, children with diarrhea exhibited a significant decrease in microbial diversity, while those with constipation showed a marked increase (p
Databáze: Directory of Open Access Journals
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