Linkage of blood cell division cycle 42 with T helper cells, and their correlation with anxiety, depression, and cognitive impairment in stroke patients

Autor: Haifeng Ma, Qing Chang, Jujuan Jia, Yaoyuan Zhang, Gang Wang, Yuanyuan Li
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Brazilian Journal of Medical and Biological Research, Vol 56 (2023)
Druh dokumentu: article
ISSN: 1414-431X
1414-431x
DOI: 10.1590/1414-431x2023e12855
Popis: Cell division cycle 42 (CDC42) regulates T helper (Th) cell differentiation and is related to psychological disorders. This study aimed to assess the correlation between blood CDC42 and Th cells, and their association with mental issues in stroke patients. Peripheral blood samples were obtained from 264 stroke patients and 50 controls. Then, serum CDC42 was measured by enzyme-linked immunosorbent assay, and Th1, Th2, and Th17 cells were detected by flow cytometry. Hospital Anxiety and Depression Scale (HADS) and Mini Mental State Examination (MMSE) were applied to patients. CDC42 was decreased (P
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