| Autor: |
Bolaji O. Oyetayo, Amos O. Abolaji, Kehinde D. Fasae, Adegbuyi Aderibigbe |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 71, Iss , Pp 104035- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2020.104035 |
| Popis: |
Aluminum is an environmental and industrial neurotoxicant known to induce oxidative damage and inflammation in tissues. Curcumin is a polyphenol with antioxidant and anti-inflammatory properties. Here, we evaluated Curcumin’s protective role in Aluminum Chloride (AlCl3)-induced toxicity in D. melanogaster. A 21-day survival analysis was carried out and subsequently, flies were exposed to AlCl3 (100 and 200 mg/kg diet) and/or Curcumin (0.2 and 0.5 mg/kg diet) for 7 days. Curcumin restored AlCl3-induced inhibition of glutathione S-transferase (GST) and catalase activities, as well as depletion of total thiol and glutathione contents. In addition, Curcumin ameliorated AlCl3-induced increase in acetylcholinesterase activity and accumulation of hydrogen peroxide and nitrite levels in flies. Additionally, AlCl3-induced disruption of climbing activity and emergence rate were ameliorated by curcumin in D. melanogaster (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect