Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial

Autor: Lambros Messinis, Grigorios Nasios, Mary H. Kosmidis, Petros Zampakis, Sonia Malefaki, Katerina Ntoskou, Anastasia Nousia, Christos Bakirtzis, Nikolaos Grigoriadis, Philippos Gourzis, Panagiotis Papathanasopoulos
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Behavioural Neurology, Vol 2017 (2017)
Druh dokumentu: article
ISSN: 0953-4180
1875-8584
DOI: 10.1155/2017/5919841
Popis: Cognitive impairment is frequently encountered in multiple sclerosis (MS) affecting between 40–65% of individuals, irrespective of disease duration and severity of physical disability. In the present multicenter randomized controlled trial, fifty-eight clinically stable RRMS patients with mild to moderate cognitive impairment and relatively low disability status were randomized to receive either computer-assisted (RehaCom) functional cognitive training with an emphasis on episodic memory, information processing speed/attention, and executive functions for 10 weeks (IG; n=32) or standard clinical care (CG; n=26). Outcome measures included a flexible comprehensive neuropsychological battery of tests sensitive to MS patient deficits and feedback regarding personal benefit gained from the intervention on four verbal questions. Only the IG group showed significant improvements in verbal and visuospatial episodic memory, processing speed/attention, and executive functioning from pre - to postassessment. Moreover, the improvement obtained on attention was retained over 6 months providing evidence on the long-term benefits of this intervention. Group by time interactions revealed significant improvements in composite cognitive domain scores in the IG relative to the demographically and clinically matched CG for verbal episodic memory, processing speed, verbal fluency, and attention. Treated patients rated the intervention positively and were more confident about their cognitive abilities following treatment.
Databáze: Directory of Open Access Journals
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