Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients

Autor: Mailton Prestes Madruga, Lucas Kich Grun, Letícya Simone Melo Dos Santos, Frederico Orlando Friedrich, Douglas Bitencourt Antunes, Marcella Elesbão Fogaça Rocha, Pedro Luis Silva, Gilson P. Dorneles, Paula Coelho Teixeira, Tiago Franco Oliveira, Pedro R.T. Romão, Lucas Santos, José Claudio Fonseca Moreira, Vinicius Schenk Michaelsen, Marcelo Cypel, Marcos Otávio Brum Antunes, Marcus Herbert Jones, Florencia María Barbé-Tuana, Moisés Evandro Bauer
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Immunity & Ageing, Vol 21, Iss 1, Pp 1-17 (2024)
Druh dokumentu: article
ISSN: 1742-4933
DOI: 10.1186/s12979-024-00423-6
Popis: Abstract Background Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage and paracrine inflammation; and obesity has been associated with premature immunosenescence, microbial translocation, and dysfunctional innate immune responses leading to poor immune response against a range of viruses and bacterial infections. Here, we have comprehensively characterized the immunosenescence, microbial translocation, and immune dysregulation established in hospitalized COVID-19 patients with different degrees of body weight. Results Hospitalised COVID-19 patients with overweight and obesity had similarly higher plasma LPS and sCD14 levels than controls (all p
Databáze: Directory of Open Access Journals
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