| Popis: |
During orthodontic tooth movement comes to remodeling of periodontal ligament and alveolar bone in response to mechanical loading. Mechanical loading, which comes from the orthodontic force causes aseptic inflammatory reaction within the periodontal tissue, which, in turn, initiates the biological processes associated with bone remodeling. As one of the controllers of the process of bone remodeling, during orthodontic treatment, it is mentioned to be interleukin-6 (IL-6). IL-6 stimulates the production of osteoclasts, ie. induces bone resorption to the osteoclastogenesis. The aim of this study was to investigate the influence of patient age on the production of interleukin-6 (IL-6) during the early stages of orthodontic tooth movement Participants were 10 children (mean age 13 years) and 10 adults (mean age 20 years) in which the orthodontic separator placed between the second premolar and first molar on one side and the opposite side served as controls. Samples were taken from treated and control teeth and before 24, 72, and 168 hours of placing the separator. Level of cytokines was determined by means of enzyme-linked whales. The content of IL-6 in gingival fluid of children and adults are remarkably different, when it comes to control, and when it comes to orthodontic treated teeth. IL-6 in gingival fluid control teeth of children was significantly lower than the content of cytokines in gingival fluid control adults. However, during orthodontic treatment, the content of IL-6 in gingival fluid is remarkably increased in children than in adults, in the comparative periods, where the trend changes in the content of this cytokine was the same in children and adults. The degree of increase is higher in children than adults which shows that the immune system of children reacts more quickly to local changes and the metabolic activity of periodontal ligament higher than in adult patients. |
