Effect of Perfluorooctanoic Acid on Kidney Function in Diabetic and Non-Diabetic Male Guinea Pigs
| Autor: | zahraa kadim shakir, Siti N. F. Muhsain, Raghad N. Al-Saadi |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | The Iraqi Journal of Veterinary Medicine, Vol 47, Iss 2 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1609-5693 2410-7409 |
| DOI: | 10.30539/ijvm.v47i2.1515 |
| Popis: | Perfluorooctanoic acid (PFOA) is a synthetic fluor-surfactant chemical used widely in products that resist oil, heat, grease, stains, and water. It is also used in producing other fluoropolymers. The main sources of exposure to PFOA are water, soil, and animal-origin food (meat, fish, and dairy products). The aim of this study to evaluate the renal function following oral gavage of sub-lethal dose of PFOA in diabetic and non-diabetic guinea pigs. The experiment run for 4 weeks, total of 40 male guinea pigs, (Cavia porcellus), were randomly selected and grouped into four equal groups. The first group (G1) served as the negative control; 2nd group (G2) alloxan induced diabetic, 3rd group (G3) non-diabetic was exposed to PFOA at 100 mg/kg BW orally/daily and 4th Group (G4) was diabetic guinea pig exposed to PFOA at 100 mg/kg BW orally/daily. Serum creatinine and histopathological alterations in the kidney tissue were evaluated. Serum creatinine concentrations were significantly increased (P |
| Databáze: | Directory of Open Access Journals |
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