From mouse genetics to targeting the Rag GTPase pathway

Autor: Ana Ortega-Molina, Alejo Efeyan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 8, Iss 5 (2021)
Druh dokumentu: article
ISSN: 2372-3556
23723556
DOI: 10.1080/23723556.2021.1979370
Popis: The identification of the Rag GTPases initiated the deciphering of the molecular puzzle of nutrient signaling to the mechanistic target of rapamycin (mTOR), and spurred interest in targeting this pathway to combat human disease. Recent mouse genetic studies have provided pathophysiological insight and pointed to potential indications for inhibitors of the Rag GTPase pathway.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje