Blood pressure control in diabetic kidney disease: a post-hoc analysis of the FANTASTIC trial

Autor: Cheol Ho Park, Soon Jun Hong, Sung Gyun Kim, Seok Joon Shin, Dong Ki Kim, Jung Pyo Lee, Sang Youb Han, Sangho Lee, Jong Chul Won, Young Sun Kang, Jongha Park, Byoung-Geun Han, Ki-Ryang Na, Kyu Yeon Hur, Yong-Jin Kim, Sungha Park, Tae-Hyun Yoo
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Clinical Hypertension, Vol 30, Iss 1, Pp 1-12 (2024)
Druh dokumentu: article
ISSN: 2056-5909
DOI: 10.1186/s40885-024-00280-x
Popis: Abstract Background The target blood pressure (BP) value is unclear for diabetic kidney disease (DKD). Therefore, we aimed to evaluate the effect of strict BP control or ‘on treatment’ BP on clinical outcomes in patients with DKD. Methods A post-hoc analysis of the prespecified secondary outcomes of the FimAsartaN proTeinuriA SusTaIned reduCtion in comparison with losartan in diabetic chronic kidney disease (FANTASTIC) trial, a randomized multicenter double-blind phase III trial. Eligible patients were aged ≥ 19 years with DKD. We assigned 341 participants with DKD to BP control strategy (standard-systolic BP [SBP]
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