Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells
| Autor: | L. S. Starykovych, M. O. Starykovych, A. N. Rechytskyi, V. A. Yeresko, T. U. Kosyak, N. O. Sybirna |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Біологічні студії, Vol 3, Iss 2, Pp 93-98 (2009) |
| Druh dokumentu: | article |
| ISSN: | 1996-4536 2311-0783 |
| DOI: | 10.30970/sbi.0302.028 |
| Popis: | Influence of spirocarbone and derivates of pyrrolopyrimidinediones (1,6-dimethyl-4-phenyl-1,2,3,4,5,7-hexahydropyrolo-[3,4-d]-pyrimidindione-2,5(1Н), and 1,6-dimethyl-4-(2-threefluoromethylphenyl)-1,2,3,4,5,7-hexahydropyrrolo-[3,4-d]-pyrimidinedione-2,5(1Н) on the leukemia cells of L1210 and CEM-T4 lines of mouse and human, respectively was studied. Cytotoxic effect of spirocarbone towards L1210 cells accompanied by apoptotic fragmentation of nuclear DNA. |
| Databáze: | Directory of Open Access Journals |
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