Evaluating Non-Conventional Chitosan Sources for Controlled Release of Risperidone

Autor: Sara Garcinuño, Inmaculada Aranaz, Concepción Civera, Concepción Arias, Niuris Acosta
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Polymers, Vol 14, Iss 7, p 1355 (2022)
Druh dokumentu: article
ISSN: 14071355
2073-4360
DOI: 10.3390/polym14071355
Popis: In this work, two chitosan samples from cuttlebone and squid pen are produced and characterized. We studied the formation of thermoresponsive hydrogels with β-glycerol phosphate and found proper formulations that form the hydrogels at 37 °C. Gel formation depended on the chitosan source being possible to produce the thermoresponsive hydrogels at chitosan concentration of 1% with cuttlebone chitosan but 1.5% was needed for squid pen. For the first time, these non-commercial chitosan sources have been used in combination with β-glycerol phosphate to prepare risperidone formulations for controlled drug delivery. Three types of formulations for risperidone-controlled release have been developed, in-situ gelling formulations, hydrogels and xerogels. The release profiles show that in-situ gelling formulations and particularly hydrogels allow an extended control release of risperidone while xerogels are not appropriate formulations for this end since risperidone was completely released in 48 h.
Databáze: Directory of Open Access Journals
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