The RSV F p27 peptide: current knowledge, important questions

Autor: Wanderson Rezende, Hadley E. Neal, Rebecca E. Dutch, Pedro A. Piedra
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Microbiology, Vol 14 (2023)
Druh dokumentu: article
ISSN: 1664-302X
DOI: 10.3389/fmicb.2023.1219846
Popis: Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein. However, questions remain about the mechanism of RSV entry and RSV F triggering and fusion promotion. This review highlights these questions, specifically those surrounding a cleaved 27 amino acids long peptide within F, p27.
Databáze: Directory of Open Access Journals