The role of vitamins K and D in the processes of ectopic calcification in patients with chronic kidney disease: The current state of the problem

Autor:	O. Susla, O. Bushtynska, S. Danyliv, L. Logoyda, A. Gozhenko
Jazyk:	English<br />Ukrainian
Rok vydání:	2022
Předmět:	chronic kidney disease cardiovascular system ectopic calcification atherosclerosis vitamin K vitamin D matrix Gla protein osteocalcin pathogenesis treatment. Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Український Журнал Нефрології та Діалізу, Iss 3(75) (2022)
Druh dokumentu:	article
ISSN:	2304-0238 2616-7352
DOI:	10.31450/ukrjnd.3(75).2022.09
Popis:	Abstract. The generalization of experimental and clinical data currently allows us to confirm the important pathogenetic role of vitamin K deficiency in cardiovascular calcification and atherosclerotic damage in chronic kidney disease (CKD). It was highlighted that, apart from vitamin K, the activity and expression of matrix Gla protein, which strongly inhibits vascular calcification, depended to a considerable extent on vitamin D. The efficacy and safety of the combined intake of vitamin K and D in slowing the progression of ectopic calcification, reducing cardiovascular risk, and improving prognosis in CKD patients need to be confirmed in multicenter randomized controlled trials.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7b0cdce699d2405794e70f662814e1c8 Zobrazit plný text záznamu View record in DOAJ