Electrical Signal Guided Ibuprofen Release from Electrodeposited Chitosan Hydrogel

Autor: Youyu Liu, Kun Yan, Guoxia Jiang, Yuan Xiong, Yumin Du, Xiaowen Shi
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: International Journal of Polymer Science, Vol 2014 (2014)
Druh dokumentu: article
ISSN: 1687-9422
1687-9430
DOI: 10.1155/2014/736898
Popis: Electrical signal guided drug release from conductive surface provides a simple and straightforward way for advanced drug delivery. In this study, we investigated the ibuprofen release from electrodeposited chitosan hydrogel by applying electrical signals. Specifically, chitosan hydrogel was electrodeposited on titanium plate and used as a matrix for ibuprofen load and release. The release of ibuprofen from the chitosan hydrogel on titanium plate was pH sensitive. By applying a positive or negative electrical potential, the release rate of ibuprofen from the electrodeposited chitosan can be facilely controlled. Thus, coupling chitosan electrodeposition and electrical signal control spurs new possibilities for biopolymeric coating and drug elution on conductive implants.
Databáze: Directory of Open Access Journals
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